2025 \u5e74 4 \u6708\uff0c\u7f8e\u56fd eGenesis \u516c\u53f8\u83b7\u5f97 FDA \u6279\u51c6\u5f00\u5c55\u57fa\u56e0\u7f16\u8f91\u732a\u809d\u7684 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u65b9\u6848\u4e0d\u662f\u76f4\u63a5\u79fb\u690d\uff0c\u800c\u662f\u5c06\u60a3\u8005\u8840\u6db2\u6cf5\u5165\u732a\u809d\u8fdb\u884c\u4f53\u5916\u8fc7\u6ee4\u3002\u8fd9\u4e0e 2024 \u5e74 3 \u6708\u4e2d\u56fd\u56e2\u961f\u5c06\u57fa\u56e0\u7f16\u8f91\u732a\u809d\u8f85\u52a9\u79fb\u690d\u5230\u8111\u6b7b\u4ea1\u60a3\u8005\u4f53\u5185\u7684\u65b9\u6848\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\uff0c\u4e5f\u4e0d\u540c\u4e8e\u5fc3\u810f\u548c\u80be\u810f\u5f02\u79cd\u79fb\u690d\u5df2\u6709\u7684\u6d3b\u4f53\u60a3\u8005\u5c1d\u8bd5\u3002\u4e3a\u4ec0\u4e48\u809d\u810f\u7684\u4e34\u5e8a\u8def\u5f84\u5982\u6b64\u7279\u6b8a\uff1f\u6211\u7684\u8c03\u67e5\u8868\u660e\uff0c\u8fd9\u53cd\u6620\u4e86\u809d\u810f\u72ec\u7279\u7684\u514d\u75ab\u539f\u6027\u548c\u4ee3\u8c22\u590d\u6742\u6027\u2014\u2014\u4f53\u5916\u8de8\u5faa\u73af\u4e0d\u662f\u6280\u672f\u9000\u6b65\uff0c\u800c\u662f\u5bf9\u809d\u810f\u751f\u7406\u7279\u6027\u7684\u66f4\u660e\u667a\u56de\u5e94\u3002<\/p>\n
2024 \u5e74 3 \u6708 14 \u65e5\uff0c\u7a7a\u519b\u519b\u533b\u5927\u5b66\u897f\u4eac\u533b\u9662\u7aa6\u79d1\u5cf0\u9662\u58eb\u56e2\u961f\u5ba3\u5e03\u5b8c\u6210\u5168\u7403\u9996\u4f8b\u57fa\u56e0\u7f16\u8f91\u732a\u809d\u7684\u4eba\u4f53\u79fb\u690d\u3002\u4f9b\u4f53\u732a\u6765\u81ea\u6210\u90fd\u4e2d\u79d1\u5965\u683c\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u8fdb\u884c\u4e86 6 \u5904\u57fa\u56e0\u7f16\u8f91\uff08\u6572\u9664 3 \u4e2a\u732a\u6297\u539f\u57fa\u56e0 GTKO\u3001CMAH\u3001B4GALNT2\uff0c\u8f6c\u5165 3 \u4e2a\u4eba\u7c7b\u57fa\u56e0 hCD46\u3001hCD55\u3001hTBM\uff09\u3002\u79fb\u690d\u5bf9\u8c61\u662f\u4e00\u4f4d\u8111\u6b7b\u4ea1\u60a3\u8005\uff0c\u624b\u672f\u5f8c\u732a\u809d\u6062\u590d\u8840\u6d41\u540e\u5373\u523b\u5206\u6ccc\u80c6\u6c41\uff0c\u672a\u89c1\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\uff0c\u6301\u7eed\u5de5\u4f5c\u8d85\u8fc7 96 \u5c0f\u65f6\u6765\u6e90 1<\/a>\u3002<\/p>\n \u4e00\u5e74\u591a\u5f8c\uff0c2025 \u5e74 4 \u6708 15 \u65e5\uff0ceGenesis \u516c\u53f8\u4e0e\u82f1\u56fd OrganOx \u516c\u53f8\u8054\u5408\u5ba3\u5e03\u83b7\u5f97 FDA \u7684 IND \u6279\u51c6\uff0c\u5f00\u5c55\u57fa\u56e0\u7f16\u8f91\u732a\u809d\uff08EGEN-5784\uff09\u7684 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4f46\u65b9\u6848\u622a\u7136\u4e0d\u540c\uff1a\u60a3\u8005\u7684\u8840\u6db2\u5c06\u88ab\u6cf5\u5165\u732a\u809d\u8fdb\u884c\u8fc7\u6ee4\uff0c\u7136\u5f8c\u8fd4\u56de\u4f53\u5185\u2014\u2014\u8fd9\u662f\u4e00\u79cd\u4f53\u5916\u8de8\u5faa\u73af\uff08extracorporeal liver cross-circulation, ELC\uff09\u7cfb\u7edf\uff0c\u800c\u975e\u76f4\u63a5\u79fb\u690d\u6765\u6e90 2<\/a>\u6765\u6e90 3<\/a>\u3002<\/p>\n \u66f4\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5fc3\u810f\u548c\u80be\u810f\u7684\u5f02\u79cd\u79fb\u690d\u5df2\u7ecf\u8d70\u5f97\u66f4\u8fdc\uff1a2022 \u5e74\u548c 2023 \u5e74\uff0c\u9a6c\u91cc\u5170\u5927\u5b66\u533b\u5b66\u9662\u5b8c\u6210\u4e86\u4e24\u4f8b\u6d3b\u4f53\u60a3\u8005\u7684\u57fa\u56e0\u7f16\u8f91\u732a\u5fc3\u810f\u79fb\u690d\uff08\u60a3\u8005\u5206\u522b\u5b58\u6d3b\u7ea6 2 \u4e2a\u6708\u548c 40 \u5929\uff09\uff1b\u7ebd\u7ea6\u5927\u5b66\u6717\u683c\u5c3c\u533b\u5b66\u4e2d\u5fc3\u5219\u5b8c\u6210\u4e86\u591a\u4f8b\u57fa\u56e0\u7f16\u8f91\u732a\u80be\u810f\u79fb\u690d\u5230\u8111\u6b7b\u4ea1\u60a3\u8005\u548c\u6d3b\u4f53\u60a3\u8005\u7684\u5c1d\u8bd5\u6765\u6e90 1<\/a>\u3002<\/p>\n \u4e3a\u4ec0\u4e48\u809d\u810f\u7684\u4e34\u5e8a\u7b56\u7565\u5982\u6b64\u4fdd\u5b88\uff1f\u8fd9\u80cc\u540e\u662f\u809d\u810f\u72ec\u7279\u7684\u751f\u7406\u6311\u6218\u3002<\/p>\n \u5728\u6211\u67e5\u9605\u7684\u8d44\u6599\u4e2d\uff0c\u809d\u810f\u5f02\u79cd\u79fb\u690d\u9762\u4e34\u4e09\u4e2a\u5fc3\u810f\u548c\u80be\u810f\u6ca1\u6709\u7684\u7279\u6b8a\u96be\u9898\uff1a<\/p>\n \u7b2c\u4e00\uff0c\u51dd\u8840\u529f\u80fd\u7d0a\u4e71\u3002<\/strong>\u809d\u810f\u662f\u4eba\u4f53\u51dd\u8840\u56e0\u5b50\u548c\u6297\u51dd\u56e0\u5b50\u7684\u4e3b\u8981\u751f\u4ea7\u5668\u5b98\u3002\u732a\u4e0e\u4eba\u4e4b\u95f4\u7684\u51dd\u8840\u8c03\u8282\u86cb\u767d\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0c\u5373\u4f7f\u8fdb\u884c\u4e86\u57fa\u56e0\u7f16\u8f91\uff08\u5982\u8f6c\u5165\u4eba TBM\uff09\uff0c\u5f02\u79cd\u732a\u809d\u4ecd\u53ef\u80fd\u5f15\u53d1\u4e25\u91cd\u7684\u51dd\u8840\u529f\u80fd\u969c\u788d\u30022022 \u5e74\u9996\u4f8b\u732a\u5fc3\u810f\u79fb\u690d\u60a3\u8005\u6700\u7ec8\u51fa\u73b0\u6bdb\u7ec6\u8840\u7ba1\u635f\u4f24\u548c\u8840\u6813\u6027\u5fae\u8840\u7ba1\u75c5\u53d8\uff0c\u90e8\u5206\u539f\u56e0\u5c31\u4e0e\u51dd\u8840\u5f02\u5e38\u6709\u5173\u6765\u6e90 1<\/a>\u3002\u809d\u810f\u4f5c\u4e3a\u51dd\u8840\u7cfb\u7edf\u7684"\u6307\u6325\u4e2d\u5fc3"\uff0c\u76f4\u63a5\u79fb\u690d\u7684\u98ce\u9669\u66f4\u9ad8\u3002<\/p>\n \u7b2c\u4e8c\uff0c\u514d\u75ab\u539f\u6027\u66f4\u5f3a\u3002<\/strong>\u809d\u810f\u542b\u6709\u4e30\u5bcc\u7684 Kupffer \u7ec6\u80de\uff08\u809d\u810f\u7279\u6709\u7684\u5de8\u566c\u7ec6\u80de\uff09\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u8bc6\u522b\u5e76\u653b\u51fb\u5916\u6765\u7ec4\u7ec7\u3002\u540c\u65f6\uff0c\u809d\u810f\u4e5f\u662f\u8865\u4f53\u7cfb\u7edf\u6fc0\u6d3b\u7684\u91cd\u8981\u573a\u6240\u3002\u4e2d\u56fd\u56e2\u961f\u4f7f\u7528\u7684 6 \u57fa\u56e0\u7f16\u8f91\u732a\u6572\u9664\u4e86\u4e09\u4e2a\u4e3b\u8981\u6297\u539f\uff08GTKO\u3001CMAH\u3001B4GALNT2\uff09\u5e76\u8f6c\u5165\u8865\u4f53\u8c03\u8282\u86cb\u767d\uff08hCD46\u3001hCD55\uff09\uff0c\u4f46\u8fd9\u4ecd\u4e0d\u8db3\u4ee5\u5b8c\u5168\u6d88\u9664\u6392\u65a5\u98ce\u9669\u6765\u6e90 1<\/a>\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0ceGenesis \u7684\u732a\u54c1\u7cfb\u8fdb\u884c\u4e86\u66f4\u591a\u57fa\u56e0\u7f16\u8f91\uff08\u5177\u4f53\u6570\u91cf\u672a\u516c\u5f00\uff09\uff0c\u4f46\u4f9d\u7136\u9009\u62e9\u4f53\u5916\u65b9\u6848\u3002<\/p>\n \u7b2c\u4e09\uff0c\u75c5\u6bd2\u4f20\u64ad\u98ce\u9669\u3002<\/strong>\u732a\u57fa\u56e0\u7ec4\u4e2d\u542b\u6709\u732a\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08PERV\uff09\u7684\u62f7\u8d1d\uff0c\u867d\u7136 eGenesis \u4f7f\u7528 CRISPR \u6280\u672f\u706d\u6d3b\u4e86\u8fd9\u4e9b\u75c5\u6bd2\uff0c\u4f46\u957f\u671f\u5b89\u5168\u6027\u4ecd\u9700\u9a8c\u8bc1\u3002\u809d\u810f\u4f5c\u4e3a\u4ee3\u8c22\u5668\u5b98\uff0c\u75c5\u6bd2\u590d\u5236\u548c\u4f20\u64ad\u7684\u98ce\u9669\u7406\u8bba\u4e0a\u9ad8\u4e8e\u5fc3\u810f\u6216\u80be\u810f\u3002<\/p>\n eGenesis \u7684\u4f53\u5916\u8de8\u5faa\u73af\u65b9\u6848\u770b\u8d77\u6765\u662f\u4e00\u79cd"\u9000\u6b65"\u2014\u2014\u4e0d\u76f4\u63a5\u628a\u732a\u809d\u653e\u8fdb\u60a3\u8005\u4f53\u5185\uff0c\u800c\u662f\u8ba9\u5b83\u5728\u5916\u9762\u5de5\u4f5c\u3002\u4f46\u5728\u6211\u770b\u6765\uff0c\u8fd9\u6070\u6070\u662f\u5bf9\u809d\u810f\u751f\u7406\u7279\u6027\u7684\u5c0a\u91cd\u3002<\/p>\n STAT News \u7684\u62a5\u9053\u6307\u51fa\uff0c\u8be5\u8bd5\u9a8c\u5c06\u62db\u52df\u6700\u591a 20 \u540d\u4e0d\u7b26\u5408\u809d\u79fb\u690d\u6761\u4ef6\u7684\u91cd\u75c7\u76d1\u62a4\u60a3\u8005\uff0c\u76ee\u7684\u662f\u8ba9\u732a\u809d\u6682\u65f6\u8fc7\u6ee4\u60a3\u8005\u8840\u6db2\uff0c\u4f7f\u60a3\u8005\u81ea\u8eab\u7684\u809d\u810f\u6709\u65f6\u95f4\u6062\u590d\uff0c\u6216\u4e89\u53d6\u65f6\u95f4\u7b49\u5f85\u4eba\u7c7b\u4f9b\u4f53\u6765\u6e90 2<\/a>\u3002\u8fd9\u662f\u4e00\u79cd"\u6865\u63a5"\u6cbb\u7597\uff0c\u800c\u975e\u6c38\u4e45\u66ff\u4ee3\u3002<\/p>\n \u8fd9\u79cd\u7b56\u7565\u7684\u4f18\u52bf\u5728\u4e8e\uff1a<\/p>\n eGenesis CEO Mike Curtis \u8868\u793a\uff0c\u6b64\u524d\u5728 4 \u5177\u9057\u4f53\u4e0a\u7684\u5b9e\u9a8c\u663e\u793a\u732a\u809d\u53ef\u4ee5\u652f\u6301\u809d\u529f\u80fd 2-3 \u5929\u6765\u6e90 2<\/a>\u3002\u8fd9\u662f\u4e00\u4e2a\u8c28\u614e\u4f46\u52a1\u5b9e\u7684\u8d77\u70b9\u3002<\/p>\n \u4e2d\u56fd\u56e2\u961f\u7684\u8f85\u52a9\u79fb\u690d\u65b9\u6848\uff08\u5c06\u732a\u809d\u690d\u5165\u4f53\u5185\u4f46\u4e0d\u5207\u9664\u60a3\u8005\u539f\u6709\u809d\u810f\uff09\u4e5f\u662f\u4e00\u79cd\u521b\u65b0\u7b56\u7565\u3002\u8f85\u52a9\u79fb\u690d\u7684\u4f18\u52bf\u5728\u4e8e\u4fdd\u7559\u60a3\u8005\u81ea\u8eab\u809d\u810f\uff0c\u5982\u679c\u732a\u809d\u5931\u6548\u53ef\u4ee5\u4f9d\u8d56\u539f\u751f\u809d\u810f\u3002\u4f46\u8fd9\u4ecd\u7136\u662f\u4f53\u5185\u79fb\u690d\uff0c\u514d\u75ab\u548c\u51dd\u8840\u98ce\u9669\u9ad8\u4e8e\u4f53\u5916\u65b9\u6848\u3002<\/p>\n \u6211\u8ba4\u4e3a\u8fd9\u9879\u7814\u7a76\u7684\u6838\u5fc3\u4ef7\u503c\u662f\u6982\u5ff5\u9a8c\u8bc1\uff1a\u5b83\u8bc1\u660e\u4e86\u57fa\u56e0\u7f16\u8f91\u732a\u809d\u5728\u4eba\u4f53\u5185\u53ef\u4ee5\u53d1\u6325\u751f\u7406\u529f\u80fd\uff08\u5206\u6ccc\u80c6\u6c41\u3001\u4ee3\u8c22\u5e9f\u7269\uff09\u8d85\u8fc7 96 \u5c0f\u65f6\uff0c\u4e14\u672a\u89c1\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\u6765\u6e90 1<\/a>\u3002\u8fd9\u662f\u540e\u7eed\u7814\u7a76\u7684\u57fa\u7840\uff0c\u4f46\u8ddd\u79bb\u771f\u6b63\u7684\u4e34\u5e8a\u5e94\u7528\u4ecd\u6709\u8ddd\u79bb\u3002<\/p>\n \u7ecf\u8fc7\u8c03\u67e5\uff0c\u6211\u7684\u5224\u65ad\u662f\uff1a<\/p>\n \u8fd9\u9879\u7814\u7a76\u503c\u5f97\u6301\u7eed\u5173\u6ce8\u7684\u5173\u952e\u8282\u70b9\u5305\u62ec\uff1a<\/p>\n \u5f02\u79cd\u79fb\u690d\u7684\u68a6\u60f3\u662f\u7528\u732a\u5668\u5b98\u89e3\u51b3\u4eba\u7c7b\u5668\u5b98\u77ed\u7f3a\u7684\u5371\u673a\u3002\u5fc3\u810f\u548c\u80be\u810f\u5df2\u7ecf\u8fc8\u51fa\u4e86\u7b2c\u4e00\u6b65\uff0c\u4f46\u809d\u810f\u7684\u8def\u5f84\u544a\u8bc9\u6211\u4eec\uff1a\u6709\u65f6\u5019\uff0c\u9000\u4e00\u6b65\u7684\u8c28\u614e\u6bd4\u8fdb\u4e00\u6b65\u7684\u6fc0\u8fdb\u66f4\u63a5\u8fd1\u6210\u529f\u3002<\/p>\n \u6458\u8981 2025 \u5e74 4 \u6708\uff0c\u7f8e\u56fd eGenesis \u516c\u53f8\u83b7\u5f97 FDA \u6279\u51c6\u5f00\u5c55\u57fa\u56e0\u7f16\u8f91\u732a\u809d\u7684 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c 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